Autism, fever, epigenetics and the locus coeruleus
نویسندگان
چکیده
منابع مشابه
The role of left and right Locus Coeruleus in formalin test in rats
Introduction: Pain as a complex process in the CNS has been extensively studied by many researchers. It has been found that pain is controlled by certain pathways in the CNS, one of most important of which is the descending noradrenergic system. The pathway begins with Locus Coeruleus (LC) nucleus and ends in the spinal cord. In this study, formalin test was used as a chemical and tonic pain...
متن کاملEpigenetics and Autism
This review identifies mechanisms for altering DNA-histone interactions of cell chromatin to upregulate or downregulate gene expression that could serve as epigenetic targets for therapeutic interventions in autism. DNA methyltransferases (DNMTs) can phosphorylate histone H3 at T6. Aided by protein kinase C β 1, the DNMT lysine-specific demethylase-1 prevents demethylation of H3 at K4. During a...
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The release of the neurotransmitter norepinephrine throughout the mammalian brain is important for modulating attention, arousal, and cognition during many behaviors. Furthermore, disruption of norepinephrine-mediated signaling is strongly associated with several psychiatric and neurodegenerative disorders in humans, emphasizing the clinical importance of this system. Most of the norepinephrine...
متن کاملThe role of locus coeruleus nucleus TRPV1 receptors in the development and expression of morphine dependence
Objective(s): This study investigated the role of locus coeruleus (LC) nucleus TRPV1 receptors (TRPV1r) in the expression and development of morphine physical dependence by intra-LC administration of AMG9810 (selective TRPV1r antagonist) in male Wistar rats. Materials and Methods: For assessing the development of morphine dependence, AMG9810 (0.0...
متن کاملThe effect of morphine on some electrophysiological parameters of paragigantocellularis and locus coeruleus nuclei interconnections
As one of the most important diffused brain modulatory systems, the nucleus locus coeruleus (LC) receives most of its afferents from the nucleus paragigantocellularis (PGi) and plays a major role in the control of drug dependence and some emotional and exciting states. For detailed investigation of the effect of morphine on relationship between these two brain stem nuclei, the activity of the r...
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ژورنال
عنوان ژورنال: Brain Research Reviews
سال: 2009
ISSN: 0165-0173
DOI: 10.1016/j.brainresrev.2008.11.001